Longevity Breakthrough: Scientists Restore “Youthful” Enzyme Activity To Combat Aging

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Innovative therapies revive a once-undruggable mitochondrial aging regulator through a revolutionary enzyme activation mechanism. Researchers at CCM Biosciences, Inc. have leveraged a novel biophysical mechanism of enzyme activation to discover and characterize groundbreaking enzyme activators for a previously untargetable master regulator of cellular energy production. These first-in-class compounds restore the enzyme’s activity to levels comparable [...]


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Rewriting History: AI Unravels the Hidden Origins of Papua New Guineans

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Genomic studies show Papua New Guineans are closely related to Asians, shaped by isolation, adaptation, and Denisovan heritage. Papua New Guineans are living proof of how isolation, ancient genetic mixing, and life on remote islands can preserve a distinct chapter of human history. A group of European scientists has recently clarified their genetic origins, applying [...] http://dlvr.it/TMnnzY
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This SAD lamp makes the winter almost bearable

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Gather ‘round and let me tell you a story about the dark sky that makes mid-afternoon feel like midnight, and the light source that makes it at all bearable. Once a year, winter appears with a quick chill of the ears and sudden craving for a vat of hot chocolate. It brings all things beautiful: holiday lights, white blankets of snow in the park and thoughtful gifts. But it also invites in the cold and heaping amounts of darkness. I came of age in upstate New York, where sunlight is gone by half past four in the afternoon the entirety of December and January. That’s to say this isn’t a new phenomenon for me, but that hasn’t made it any less painful. In fact, it has caused a feeling of dread that starts popping up come late September. But when I moved to Scotland, 4:30PM became nearly 3PM and the sun didn’t fully rise until well after I’d woken up. Even in London where I’m now based, it’s easily dark by 4PM on the shortest days. Like most people, the darkness leaves me exhausted while...
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Bitcoin poised to reclaim $90,000, according to derivatives metrics

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Bitcoin (BTC) failed to sustain levels above $85,000 on March 14, despite a 1.9% gain in the S&P 500 index. More importantly, it has been over a week since Bitcoin last traded at $90,000, prompting traders to question whether the bull market is truly over and how long selling pressure will persist. Bitcoin basis rate rebounds from bearish levels From a derivatives perspective, Bitcoin metrics have shown resilience despite a 30% drop from its all-time high of $109,354 on Jan. 20. The Bitcoin basis rate, which measures the premium of monthly contracts over spot markets, has recovered to healthy levels after briefly signaling bearish sentiment on March 13. Bitcoin 2-month futures contracts annualized premium. Source: Laevitas.ch Traders typically demand a 5% to 10% annualized premium to compensate for longer settlement periods. A basis rate below this threshold signals weak demand from leveraged buyers. While the current 5% rate is lower than the 8% recorded two weeks ago, i...
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